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Mitochondrial research

Elamipretide in cryopreservation: higher concentration was not better

Rooster sperm samples were frozen in defined extender formulations and evaluated after thawing across several elamipretide concentrations.

Preclinical studyPaper year: 2025Elamipretide (SS-31)

01 / DESIGN

What was studied?

Rooster sperm samples were frozen in defined extender formulations and evaluated after thawing across several elamipretide concentrations.

02 / FINDINGS

What did the researchers report?

Selected intermediate concentrations improved motility and membrane-related measurements. The highest tested concentration showed diminished effects and signs of toxicity.

03 / LIMITS

How should it be interpreted?

This is an avian ex-vivo preservation study, not evidence for human fertility treatment. The concentration-dependent pattern cannot be generalized to other media or materials.

Loti Labs Peptide editorial reading note. Based on the linked source record. Methods and corrections.

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