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Endocrine research

Ipamorelin in ferrets: weight loss and vomiting were different endpoints

Researchers compared two ghrelin-receptor agonists using intestinal tissue and a cisplatin-exposure ferret model.

Preclinical studyPaper year: 2024Ipamorelin

01 / DESIGN

What was studied?

Researchers compared two ghrelin-receptor agonists using intestinal tissue and a cisplatin-exposure ferret model.

02 / FINDINGS

What did the researchers report?

Both interventions attenuated delayed weight loss. Systemically delivered ipamorelin did not reduce acute or delayed vomiting; a central antiemetic result concerned anamorelin instead.

03 / LIMITS

How should it be interpreted?

Effects from another agonist or administration route cannot be assigned to ipamorelin. The animal experiment does not establish clinical supportive-care benefits.

Loti Labs Peptide editorial reading note. Based on the linked source record. Methods and corrections.

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